Brand name: doxycycline
Generic name: Monodox, Vibrox, Periostat, Doxyhexal, Vibra-Tabs, Adoxa, Doryx, Oracea, Microdox, Doxy, Doxylin, Doxycycline, vibramycin

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Usual Adult Dose for Peritonitis:1 to 2 g IV every 6 to 8 hoursMaximum dose: 2 g IV every 4 hoursDuration: 5 to 14 daysPeritoneal dialysis-associated peritonitis:Continuous: 500 mg/2 L exchange intraperitoneallyIntermittent: 2 g/ 2 L exchange intraperitoneally once a dayUsual Adult Dose for Pneumonia:1 to 2 g IV or IM every 6 to 8 hoursMaximum dose: 2 g IV every 4 hoursDuration: 7 to 21 daysUsual Adult Dose for Pyelonephritis:1 to 2 g IV or IM every 8 to 12 hoursMaximum dose: 2 g IV every 4 hoursDuration: 14 daysUsual Adult Dose for Salmonella Gastroenteritis:1 to 2 g IV or IM every 8 hoursDuration: 14 days, or longer in immunocompromised patientsUsual Adult Dose for Septicemia:2 g IV every 6 to 8 hoursMaximum dose: 2 g IV every 4 hoursDuration: 14 daysUsual Adult Dose for Sepsis:2 g IV every 6 to 8 hoursMaximum dose: 2 g IV every 4 hoursDuration: 14 daysUsual Adult Dose for Skin or Soft Tissue Infection:1 to 2 g IV or IM every 8 to 12 hoursDuration: 7 to 10 days; up to 14 to 21 days treatment may be required for severe infections such as diabetic soft tissue infectionsVibrio vulnificus: 2 g IV every 8 hours plus doxycycline 100 mg IV or orally every 12 hours or ciprofloxacin 400 mg IV every 12 hoursUsual Adult Dose for Surgical Prophylaxis:1 g IM or IV 30 to 90 minutes prior to start of surgeryCefotaxime with ampicillin is recommended for liver transplantation prophylaxis. Usual Adult Dose for Pelvic Inflammatory Disease:1 to 2 g IV or IM every 6 to 8 hoursMaximum dose: 2 g IV every 4 hoursDuration: Approximately 14 days, depending on the nature and severity of the infectionAlternatively, for treatment of mild pelvic inflammatory disease on an outpatient basis, a single 500 mg IM dose of cefotaxime, followed by oral doxycycline therapy with or without metronidazole, may be given. One case report describes severe hiccups of 4-day duration associated with esophagitis following the first dose of doxycycline. Do not use this medication if you are allergic to doxycycline, or to similar medicines such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap). Phenobarbital has been shown to shorten the half-life of doxycycline for as long as 2 weeks after barbiturate therapy is discontinued. Doxycycline therapy for 14 days (if not pregnant) is also recommended to treat possible concurrent chlamydial infection. Doxycycline therapy for 14 days is recommended if concurrent chlamydial infection is present in late postpartum patients (breast-feeding should be discontinued). Case reports of doxycycline causing Clostridium difficile have also been described.

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